To obtain the subject new compound useful for the treatment of diseases of the central nervous system and as an antipsychotic agent, an analgesic, etc.
This compound is expressed by formula I [R1 is Y or Y-(1-6C alkyl) (Y is carboxy, tetrazolyl, etc.); R2, R3 and R4 are each H, hydroxy, etc.; X and Z are each H, a 1-6C alkyl, etc.] or their salts or esters, e.g. 2-amino-2-(3- cis-carboxycyclobutyl)-3-(9-xanthyl)propionic acid. The compound of formula I is produced by hydrolyzing a compound of formula II. The hydrolysis reaction is carried out in a proper solvent (e.g. water) at a high temperature (50-200°C) in the presence of an acid (e.g. hydrochloric acid) or a base (e.g. NaOH). The starting compound of formula II is produced by reacting a compound of formula III with KCN and (NH4)2CO3 in a hydrated ethanol under a Bucherer-Bergs reaction condition at 30-120°C.
JOHN RICHARD HARRIS
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