PHENOL DERIVATIVE, MANUFACTURE AND ANTIESTROGENIC MEDICINE

Title:

PHENOL DERIVATIVE, MANUFACTURE AND ANTIESTROGENIC MEDICINE

Document Type and Number:

Japanese Patent JPS6117537

Kind Code:

A

Abstract:

Mono- or bis-complex esters or ethers of a phenol derivative of the formulawherein NU is a defined mono- or bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl;hydroxyphenyl-hydroxyindanyl, hydroxyphenyl-hydroxy--benzothienyl or di-hydrdxyphenyl-ethylene or vinylene nucleus;wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages,wherein R'is hydrogen, or alkyl, alkenyl, cycloalkyl, halogenoalkyl, aryl or arylalkyl, or R' is joined to R², and wherein X is -CONR²-, -CSNR²-,-NR¹²CO-, -NR¹²CS-, -NR¹²CONR²-,-SO₂NR²- or -CO-, or, when R¹ is not hydrogen, is -NR¹²COO-, -S-, -SO- or -S0₂-, wherein R² is hydrogen or alkyl, or R¹ and R² together form alkylene;wherein R¹² is hydrogen or alkyl, and wherein R²² is hydrogen, cyano or nitro;or a salt thereof when appropriate. The compounds possess antioestrogenic activity and may be used for the treatment of hormone-dependent breast tumours or of anovulatory infertility.

Inventors:

FUIRITSUPU NEIRU EDOWAAZU
BURAIAN SUCHIIRU TAITO

Application Number:

JP8914585A

Publication Date:

January 25, 1986

Filing Date:

April 26, 1985

Export Citation:

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Assignee:

ICI LTD

International Classes:

A61K31/16; A61K31/17; A61K31/215; A61K31/22; A61K31/265; A61K31/275; A61K31/33; A61P35/00; C07C67/00; C07C69/003; C07C69/017; C07C219/28; C07C227/00; C07C227/16; C07C227/18; C07C229/06; C07C233/12; C07C239/00; C07C271/10; C07C271/22; C07C313/00; C07C317/00; C07C317/18; C07C317/24; C07C317/28; C07C317/44; C07C323/22; C07C323/41; C07C323/52; C07C323/53; C07C323/54; C07C323/60; C07C323/65; C07D207/16; C07D307/38; C07D311/02; C07D333/54; C07D521/00; (IPC1-7): A61K31/17; A61K31/215; A61K31/275; A61K31/33; C07C69/003; C07C69/017; C07C93/187; C07C101/04; C07C125/04; C07C125/065; C07C147/02; C07C147/14; C07C149/20; C07D207/16; C07D307/38; C07D311/02; C07D333/54; C07D521/00

Domestic Patent References:

JPH0415778A

1992-01-21

Attorney, Agent or Firm:

Toshio Yano

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