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Title:
PHOSPHORAMIDATE ALKYLATOR PRODRUG
Document Type and Number:
Japanese Patent JP2012153722
Kind Code:
A
Abstract:

To provide phosphoramidate alkylator prodrugs.

The phosphoramidate alkylator prodrugs can be used to treat cancer when administered along or in combination with one or more anti-neoplastic agents. The present invention provides compounds which are hypoxia activated phosphoramidate alkylator prodrugs and methods of their synthesis, an individual isomer or a racemic or non-racemic mixture of isomers, bioisosteres, pharmacophores, a pharmaceutically acceptable salt, solvate, or hydrate.


Inventors:
MATTEUCCI MARK
DUAN JIAN-XIN
JIAO HAILONG
KAIZERMAN JACOB
AMMONS STEVE
Application Number:
JP2012112647A
Publication Date:
August 16, 2012
Filing Date:
May 16, 2012
Export Citation:
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Assignee:
THRESHOLD PHARMACEUTICALS INC
International Classes:
C07F9/24; A61K31/661; A61P35/00; A61P35/02; A61P43/00; C07F9/6506; C07F9/6539; C07F9/655; C07F9/6553; C07F9/6558; C07F9/6584; A61K33/243
Domestic Patent References:
JP2004515448A2004-05-27
JPH08509727A1996-10-15
JPH11504009A1999-04-06
JPH08509727A1996-10-15
JPH11504009A1999-04-06
JP5180824B22013-04-10
JP2004515448A2004-05-27
Foreign References:
WO2004087075A22004-10-14
US20030008850A12003-01-09
WO2004087075A22004-10-14
US20030008850A12003-01-09
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita



 
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