フタロシアニン色素コンジュゲートおよびその保存法

Japanese Patent JP7425026

B2

Provided are methods for manufacturing a conjugate containing a phthalocyanine dye, including methods that include one or more steps of preparing or producing the conjugate, formulating the conjugate and packaging the conjugate. In some aspects, the manufacturing methods result in the generation of a stable conjugate. Also provided are stable phthalocyanine dye conjugates, compositions and articles of manufacture containing the stable conjugates, and methods for their administration to subjects for photoimmunotherapy. In some embodiments, the phthalocyanine dye conjugates are conjugated to a targeting molecule, such as an antibody, that targets the conjugate to a cell or pathogen, such as by binding to a cell surface protein.

Makings Luis Earl.
Heim Roger
Garcia-Guzman Miguel
Chin Eileen Sun
Yardav Deepak
Von Jerry

JP2021145917A

January 30, 2024

September 08, 2021

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Lacten Medical, Inc.

A61K47/54; A61K31/409; A61K31/695; A61K39/395; A61K45/00; A61K47/04; A61K47/68; A61P25/00; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00

JP2018528267A

PLOS ONE,2015年03月23日,Vol. 10, No. 3,pp. 1-11,DOI:10.1371/journal.pone.0121989
Molecules,2012年,Vol. 17,pp. 98-144

Hatsushi Shimizu
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto

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