To provide piperazine derivatives useful as selective CCR5 antagonists, pharmaceutical compositions containing compounds thereof, and methods of treatment using the compounds.
There are provided: the method, as for the treatment of HIV, comprising administering to a human in need of such treatment an effective amount of a CCR5 antagonist; the pharmaceutical composition for the treatment of HIV comprising an effective amount of a CCR5 antagonist in combination with a pharmaceutically acceptable carrier; and the pharmaceutical composition for the treatment of solid organ transplant rejection, graft vs host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies, or multiple sclerosis comprising an effective amount of a CCR5 antagonist in combination with a pharmaceutically acceptable carrier.
CLADER JOHN W
JOSIEN HUBERT B
MCCOMBIE STUART W
MCKITTRICK BRIAN A
MILLER MICHAEL W
NEUSTADT BERNARD R
PALANI ANANDAN
STEENSMA RUO
TAGAT JAYARAM R
VICE SUSAN F
LAUGHLIN MARK A
| WO1998005292A2 | 1998-02-12 | |||
| WO1998006697A1 | 1998-02-19 | |||
| WO1998004125A1 | 1998-02-05 | |||
| WO1999004794A1 | 1999-02-04 |
Takaaki Yasumura
Natsuki Morishita