Title:
PIPERAZINE DERIVATIVE
Document Type and Number:
Japanese Patent JP3220591
Kind Code:
B2
Abstract:
PURPOSE: To obtain a compound having calmodulin-inhibiting action and, at the same time, having brain-protecting action and useful for treatment for circulatory diseases and brain region diseases, e.g. hypertension, heart failure, angina pectoris, cerebral apoplexy, cerebral infarction, Alzheimer's disease and Parkinsonian disease.
CONSTITUTION: A compound of formula I(Q is an aryl, a heterocycle, a diarylmethyl or an aralkyl; R is a bicyclic nitrogen-containing heterocycle or phenyl; Z is a 1-3C alkylene, a 2-4C alkenylene, a 1-3C alkylene having one OH group, carbonyl atomic group, etc.), e.g. 3-[2-[4-(3-chloro-2-methylphenyl)-1- piperazinyl]-ethyl]-5,6-dimethoxy-1-(3,4-dimethoxybenzyl)-1H-indazole. The compound of formula I is obtained by reacting a carboxylic acid derivative of the formula R-Z-COOH with a piperazine derivative of formula II to afford an amino compound of formula III and reducing the resultant compound of formula III.
Inventors:
Kenjiro Yamamoto
Atsushi Hasegawa
Hideki Kubota
Masahiro Ando
Yamaguchi et al.
Atsushi Hasegawa
Hideki Kubota
Masahiro Ando
Yamaguchi et al.
Application Number:
JP9939194A
Publication Date:
October 22, 2001
Filing Date:
May 13, 1994
Export Citation:
Assignee:
Daiichi Pharmaceutical Co., Ltd.
International Classes:
A61K31/40; A61K31/4015; A61K31/4025; A61K31/403; A61K31/4035; A61K31/404; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/4422; A61K31/4427; A61K31/443; A61K31/455; A61K31/495; A61K31/496; A61K31/4965; A61K31/505; A61K31/506; A61K31/535; A61K31/5375; A61K31/5377; A61P7/10; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P13/02; A61P15/00; A61P25/00; A61P25/16; A61P25/28; A61P43/00; C07D207/27; C07D295/08; C07D207/325; C07D207/327; C07D207/335; C07D209/14; C07D209/16; C07D209/34; C07D209/46; C07D209/48; C07D211/90; C07D213/30; C07D213/38; C07D213/50; C07D213/80; C07D231/56; C07D241/04; C07D295/04; C07D295/096; C07D295/112; C07D295/116; C07D295/12; C07D295/135; C07D295/18; C07D295/185; C07D317/58; C07D333/20; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/06; C07D403/08; C07D403/10; C07D403/12; C07D403/14; C07D405/04; C07D405/06; C07D405/10; C07D405/12; C07D405/14; C07D409/10; C07D413/14; C07D491/04; C07D491/048; C07D491/056; C12N9/99; C07D207/26; C07D207/32; (IPC1-7): C07D207/325; A61K31/40; A61K31/455; C07D207/27; C07D207/327; C07D207/335; C07D209/14; C07D209/46; C07D211/90; C07D213/38; C07D213/50; C07D213/80; C07D231/56; C07D295/08; C07D295/12; C07D295/18; C07D317/58; C07D333/20; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/10; C07D403/12; C07D405/04; C07D405/12; C07D491/048; C07D491/056
Domestic Patent References:
| JP58203966A |
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