ADおよび関連状態の治療のためのピペラジン誘導体

Japanese Patent JP2010518064

A

Compounds of formula (I) selectively inhibit production of Aβ(1-42) and hence find use in treatment of Alzheimer's disease and other conditions associated with deposition of A(β) in the brain.

JP2001524467	Title of the invention Heteroarylaminoguanidine and alkoxyguanidines and their use as protease inhibitors.
JP6738369	Biarylamide compounds as kinase inhibitors
JP2010531889	Composition containing tryptophan hydroxylase inhibitor

Blaton, Peter
Frettier, Stephen
Tayl, martyne
Harrison, Tamothy
Muniyos, Benito
Ribkin, Alexei
Humblett, Christopher
Sirif Ivan, Pin
Otute, Karin

JP2009548752A

May 27, 2010

February 11, 2008

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Merck Sharp End Dome Corporation
Merck Sharp End Dome Limited

C07D213/74; A61K31/496; A61K31/497; A61K31/506; A61K31/517; A61K31/519; A61K31/53; A61K31/5377; A61P25/28; C07D213/75; C07D213/79; C07D213/81; C07D213/82; C07D213/85; C07D239/42; C07D239/48; C07D241/20; C07D241/26; C07D285/08; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/14; C07D405/14; C07D413/14; C07D471/04; C07D487/04; C07D487/08; C07D495/04

Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura

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