To obtain a compound which manifests an excellent CCR5 antagonistic action and useful as a drug for HIV infection of human peripheral blood mononuclear cells, in particular, for prevention and treatment of AIDS.
The compound is represented by formula (1) [wherein A is a group represented by formula (I) {wherein R3 represents a hydrocarbon group which may contain substituent groups, or the like; X represents a junction, SO2, or, CO; (n) is an integrer from 1 to 3; and R4 and R5 may be the same or different, each of which represents hydrogen atom or a C1-6 alkyl group}; (r) is an integer from 2 to 4; B represents a junction CH2, SO2, or the like; each of (p) and (q) is an intergrer 0, or from 1 to 4; R1 represents a halogen atom, a 1-6C alkyl group, or the like; and R2 represents a hologen, a 1-6C alkyl, or SO2Rd (wherein Rd represents a -6C alkyl group or a 3-8C cycloalkyl group)]. The compound includes a salt thereof.
SUGIHARA YOSHIHIRO
KANZAKI NAOYUKI
NISHIMURA TADASHI
BABA MASANORI
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