PLASMODIUM FALCIPARUM SPOROZOITE AND LIVER STAGE ANTIGENS

Japanese Patent JP2014169291

A

PROBLEM TO BE SOLVED: To provide an immunogenic protein for use as an anti-malaria vaccine component, and a peptide with a DNA sequence, and to provide a method for inducing an immune response to these antigens.SOLUTION: The invention relates to an immunogenic composition characterized by having a specific amino acid sequence having a DNA sequence which is derived from Plasmodium falciparum, and to an immunogenic composition encoded by a specific nucleic acid sequence. Furthermore, a polypeptide with a specific amino acid sequence encoded by a specific nucleic acid sequence is preferred to be contained. It can be used to induce an immune response to malaria in mammals by administering a vaccine formulation containing the antigen, or expressing the antigen so as to be carried by DNA or other nucleic acid expression systems as a vaccine formulation.

KEITH LIMBACH
JOAO AGUIAR
MARTHA SEDEGAH
THOMAS RICHIE

JP2014047538A

September 18, 2014

March 11, 2014

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US GOVERNMENT

A61K39/00; A61K48/00; A61P33/06; C12N15/09

JP2002537310A

2002-11-05

WO2007060550A2	2007-05-31
WO2009021931A1	2009-02-19
WO2008000261A2	2008-01-03
WO2008122769A2	2008-10-16

JPN5012015858; ＵＮＩＰＲＯＴ　ＳＵＢＭＩＳＳＩＯＮ: 'Ｑ８１ＢＢ９＿ＰＬＡＦ７' ［ＯＮＬＩＮＥ］ Ｖ１９, 200911
JPN6015041405; Ｄａｔａｂａｓｅ　ＵｎｉＰｒｏｔＫＢ／Ｓｗｉｓｓ-Ｐｒｏｔ［ｏｎｌｉｎｅ］，Ａｃｃ．Ｎｏ．Ｏ７７３４０ , 200610

Mitsuru Kimura
Takanori Menju
Taiji Morikawa
Yasuhito Amemiya
Kei Sakurada

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