Title:
【発明の名称】腫瘍壊死因子とインターロイキン-4の相乗作用
Document Type and Number:
Japanese Patent JP3226918
Kind Code:
B2
Abstract:
A composition of matter which comprises Tumor Necrosis Factor (TNF) and Interleukin-4 (IL-4) has been disclosed. This composition inhibited the growth of human breast cancer cells, human vulvar carcinoma cells and human histiocytic lymphoma cells a dose-dependent manner. The growth characteristics of human breast cancer cells were minimally affected when exposed to TNF or IL-4 alone. However, the combination of these two cytokines together inhibited the growth of these cells in a dose-dependent manner. Additionally, interferon-gamma (IFN-g) caused a further potentiation of the antiproliferative effects of the TNF and IL-4 composition.
Inventors:
Agarwal, Balat
Application Number:
JP50065192A
Publication Date:
November 12, 2001
Filing Date:
October 01, 1991
Export Citation:
Assignee:
Research Development Foundation
International Classes:
A61K38/20; A61K38/21; A61K38/00; A61K45/06; A61P35/00; A61K; (IPC1-7): A61K38/00; A61K45/06; A61P35/00
Domestic Patent References:
| JP6140221A | ||||
| JP632930A |
Other References:
【文献】米国特許4770995(US,A)
Attorney, Agent or Firm:
Morio Sada