Title:
Polypeptide with sialylated sugar chain added
Document Type and Number:
Japanese Patent JP6368706
Kind Code:
B2
Abstract:
The object of the present invention is to provide a polypeptide having interferon ² activity glycosylated with highly uniform sialylated sugar chains. The present invention is a glycosylated polypeptide, wherein the polypeptide is any polypeptide selected from the group consisting of the following (1) to (4);
(1) a polypeptide consisting of the amino acid sequence represented by SEQ ID NO. 1,
(2) a polypeptide having one or a few amino acids deleted, substituted, or added in the polypeptide consisting of the amino acid sequence represented by SEQ ID NO. 1,
(3) a polypeptide that is an analog of interferon ², and
(4) a polypeptide having 80% or more homology to the polypeptide consisting of the amino acid sequence represented by SEQ ID NO. 1,
in which amino acids at 4 to 6 locations are substituted with glycosylated amino acids, and
wherein all of the non-reducing terminals of said sugar chain are sialylated.
Inventors:
Ouchi Masateru
Nishihara Mika
Katsunari Tezuka
Maeda Masatoshi
Yasuhiro Kajiwara
Izumi Sakamoto
Nishihara Mika
Katsunari Tezuka
Maeda Masatoshi
Yasuhiro Kajiwara
Izumi Sakamoto
Application Number:
JP2015508500A
Publication Date:
August 01, 2018
Filing Date:
March 24, 2014
Export Citation:
Assignee:
Glycotechnology Institute Inc.
International Classes:
C07K14/565; A61K38/21; A61P1/16; A61P17/00; A61P25/00; A61P35/00
Domestic Patent References:
| JP2011024597A | ||||
| JP2009242372A |
Foreign References:
| WO2013002330A1 | ||||
| WO2009153960A1 | ||||
| WO2012121206A1 |
Other References:
Journal of the American Chemical Society,2012年,Vol.134,p.5428-5431
Attorney, Agent or Firm:
Masahiro Nanjo
Ayako Seta
Koichiro Inami
Hidetoshi Hara
Ayako Seta
Koichiro Inami
Hidetoshi Hara