Title:
POLYSACCHARIDE VACCINE FOR STAPHYLOCOCCAL INFECTIONS
Document Type and Number:
Japanese Patent JP2019089845
Kind Code:
A
Abstract:
To provide polysaccharide vaccine for Staphylococcal infections.SOLUTION: The invention relates to compositions of a deacetylated poly N-acetylated glucosamine (dPNAG) of Staphylococci. The dPNAG may be isolated from natural sources or synthesized de novo. The invention also relates to the use of dPNAG as a vaccine for inducing active immunity to infections caused by Staphylococcus aureus, S. epidermidis, other related coagulase-negative or coagulase-positive Staphylococci, and other organisms carrying the ica (intracellular adhesion) locus. The invention further provides methods of use for antibodies directed to dPNAG, particularly for inducing passive immunity to the same level of infections.SELECTED DRAWING: None
Inventors:
PIER GERALD B
MAIRA-LITRAN TOMAS
MAIRA-LITRAN TOMAS
Application Number:
JP2019035315A
Publication Date:
June 13, 2019
Filing Date:
February 28, 2019
Export Citation:
Assignee:
BRIGHAM & WOMENS HOSPITAL INC
International Classes:
A61K39/00; A61K9/08; A61K31/715; A61K31/726; A61K35/26; A61K35/28; A61K35/74; A61K39/085; A61K47/64; A61P31/04; A61P37/04; C07K16/12; C12N1/20; C12N15/06; C12N15/13; C12P19/04; C12P21/08; G01N33/53; G01N33/533; G01N33/534; G01N33/535; G01N33/569
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita