PURPOSE: To obtain the subject apparatus capable of efficiently producing cells at a high density for a long period by equipping a stirred type incubator or a bioreactor for a microorganism, a cell or an immobilized enzyme with a filtering and separating membrane for filtering and separating a culture solution or a reactional solution parallel to the culture or reaction.
CONSTITUTION: A stirred type incubator or a stirred type bioreactor is composed of an outer vessel 2 having a culture solution taking out pipe 7 and an aeration pipe 12 and an upper lid 3 equipped with a substrate solution feed pipe 5, a culture solution circulating feed pipe 6 and an aeration pipe 11 and has a stirrer 4 in the interior. A ceramic porous cylinder 1 as a porous separation membrane for filtering and separating a culture solution or a reactional solution is installed in this incubator or bioreactor and its interior is separated into a culturing part or a reactional part and a filtering part by the partition wall (porous cylinder) 1 composed of the porous separation membrane. Thereby, a microorganism, a cell or an immobilized enzyme is filled and cultured or reacted to maintain the cell or immobilized enzyme at a high density in the culture or reactional solution. As a result, the product is continuously produced with a high efficiency.
KOMINAMI MINORU
CHUO SETSUBI ENG KK
| JPS6192562A | 1986-05-10 | |||
| JPS6212997A | 1987-01-21 |
Agata Akira (1 person outside)