Title:
【発明の名称】プレグナン誘導体
Document Type and Number:
Japanese Patent JPH0660195
Kind Code:
B2
Abstract:
The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via intermediates having the natural steroid configuration at the 20-position. These novel intermediates are prepared from 17-keto steroids by reaction with ethyltriphenylphosphonium halides followed by reaction with formaldehyde to form comounds having the natural steroid configuration at the 20-position and which are suitable substrates for the preparation of the aforementioned Vitamin D3 metabolites.
Inventors:
Andrew Day Batchiyo
Donald E. Berger Giunia
Milan Earl Uskokovic
Donald E. Berger Giunia
Milan Earl Uskokovic
Application Number:
JP35652091A
Publication Date:
August 10, 1994
Filing Date:
December 25, 1991
Export Citation:
Assignee:
F. Hoffman-La Rochille Age
International Classes:
C07J9/00; C07J7/00; C07J11/00; C07J13/00; C07J17/00; C07J31/00; C07J53/00; (IPC1-7): C07J13/00
Attorney, Agent or Firm:
Heiyoshi Odashima
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