Title:
非晶質アトルバスタチンカルシウムの調製
Document Type and Number:
Japanese Patent JP4336106
Kind Code:
B2
Abstract:
Non-crystalline, in particular amorphous, pharmaceutically acceptable atorvastatin salts, especially the calcium salt, are prepared from atorvastatin lactone or from a compound of formula (I) where A denotes a common protecting group or separate protecting groups for the two hydroxy groups, and B denotes a carboxylic acid protecting group, without the need of prior formation of atorvastatin lactone, the crystalline form of the atorvastatin salt, or a mixture of amorphous and crystalline forms of the atorvastatin salt. Pharmaceutical formulations are prepared from these salts.
Inventors:
Solsaku, Gorazd
Application Number:
JP2002559389A
Publication Date:
September 30, 2009
Filing Date:
January 22, 2002
Export Citation:
Assignee:
LK Pharmaceutical and Chemical Company D.D.
International Classes:
C07D207/34; C07D405/06; A61P3/00; A61P7/00
Domestic Patent References:
| JP3058967A | ||||
| JP8507521A | ||||
| JP11510486A | ||||
| JP2003516388A |
Other References:
Tetrahedron Letters,1992年,33,17,2283-2284
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura