モノアミン神経伝達物質によって影響を受ける病態の処置における(+)-1-(3,4-ジクロロフェニル)-3-アザビシクロ[3.1.0]ヘキサンの調製および使用

Title:

モノアミン神経伝達物質によって影響を受ける病態の処置における(+)-1-(3,4-ジクロロフェニル)-3-アザビシクロ[3.1.0]ヘキサンの調製および使用

Document Type and Number:

Japanese Patent JP2013544850

Kind Code:

A

Abstract:

The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated derivatives, metabolites, solvates, hydrates, and/or prodrugs of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and their use alone or in combination with additional psychotherapeutic compositions in the treatment of conditions affected by monoamine neurotransmitters, including treatment of refractory individuals.

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Inventors:

McKinney, Anthony, Alexander
Bimaster, frank
Piskolsky, Walter

Application Number:

JP2013542235A

Publication Date:

December 19, 2013

Filing Date:

December 02, 2011

Export Citation:

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Assignee:

Eusimics bioscience, ink.

International Classes:

A61K31/403; A61K9/12; A61K9/22; A61K9/70; A61K45/00; A61K47/36; A61K47/38; A61P25/24

Domestic Patent References:

JP2005500983A	2005-01-13
JP2008510715A	2008-04-10
JPS5813568A	1983-01-26

Other References:

JPN6015046203; 'Ｅｆｆｉｃａｃｙ　ａｎｄ　Ｓａｆｅｔｙ　ｏｆ　ＤＯＶ　２１，９４７　ｉｎ　ｔｈｅ　Ｔｒｅａｔｍｅｎｔ　ｏｆ　Ｍａｊｏｒ　Ｄｅｐｒｅｓｓｉｖｅ　Ｄｉｓｏｒｄｅｒ' ＣｌｉｎｉｃａｌＴｒｉａｌｓ．ｇｏｖ , 2008
JPN6015046205; Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　ＰｈａｒｍａｃｏｌｏｇｙＶｏｌ．４６１, 2003, ｐ．９９-１０４
JPN6015046208; ＮｅｕｒｏＲｘ（Ｒ）Ｖｏｌ．３, 2006, ｐ．４２-５６
JPN6016034720; Ｅｘｐｅｒｔ　Ｏｐｉｎ．　Ｉｎｖｅｔｉｇ．　ＤｒｕｇｓＶｏｌ．１６，　Ｎｏ．９, 2007, ｐ．１３６５-１３７７

Attorney, Agent or Firm:

Hiroe Associates Patent Office

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