PRODUCTION OF ANTIBIOTIC NK86-0084

Title:

PRODUCTION OF ANTIBIOTIC NK86-0084

Document Type and Number:

Japanese Patent JPH01175970

Kind Code:

A

Abstract:

PURPOSE: To obtain the title substance useful as an antibacterial agent, antitumor agent and inhibitor of arterialization, by selectively reducing para- quinone part of herbimycin A with a reducing agent such as ascorbic acid.

CONSTITUTION: Herbimycin A shown by formula I is dissolved in methanol and stirred with ascorbic acid dissolved in water at room temperature for 1hr to give a compound shown by formula II. The reaction is carried out in an inert solvent (e.g. hydrous methanol) and advance of the reaction can be readily observed by analytical method of silica gel thin layer chromatography.

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Inventors:

SAITO SEIICHI
YAMAZAKI MASAKUNI
SHIMADA NOBUYOSHI

Application Number:

JP33021187A

Publication Date:

July 12, 1989

Filing Date:

December 28, 1987

Export Citation:

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Assignee:

NIPPON KAYAKU KK

International Classes:

C07D225/06; A61K31/395; A61P9/00; A61P31/04; A61P35/00; A61P43/00; (IPC1-7): A61K31/395; C07D225/06

Attorney, Agent or Firm:

Kazuhiko Takeda

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