Title:
PRODUCTION OF ARYLACRYLIC ACIDS AND THEIR ESTERS
Document Type and Number:
Japanese Patent JP3338101
Kind Code:
B2
Abstract:
PURPOSE: To produce arylacrylic acids and their esters from an arylamine in a high yield without first isolating a diazonium salt by using a low concn. palladium catalyst.
CONSTITUTION: An arylamine of formula I (where Ar is an arom. group or a hetero arom. group) is converted into a diazonium salt preferably with a stoichiometric amt. of nitrous acid in an aq. medium. The diazonium salt is then allowed to react with an olefinic matrix of formula II [where Z is R2 or CH2COOR3; and R1 to R3 are each H or CnH2n+1 (0≤n≤20)] in the aq. medium in the presence of a palladium catalyst and a carboxylic acid of formula III (where R4 is H, Cl, CH3, or C2H5) preferably at 0-30°C to obtain the objective arylacrylic acids and their salts. Excess nitrous acid is preferably removed by adding a nitrous acid scavenger such as a prim. amine or amide after the formation of the diazonium salt and before the addition of the catalyst.
Inventors:
Alan J. Chalk
Joseph A. Bergillo
Lasso Rower Simmer
Cereza bee.
Joseph A. Bergillo
Lasso Rower Simmer
Cereza bee.
Application Number:
JP937593A
Publication Date:
October 28, 2002
Filing Date:
January 22, 1993
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
B01J31/22; C07B61/00; C07C51/347; C07C51/353; C07C51/367; C07C59/64; C07C67/343; C07C69/54; C07C69/612; C07C69/65; C07C69/734; C07C69/738; C07C69/76; C07C201/12; C07C205/56; C07C231/12; C07C233/11; B01J31/12; C07C233/65; C07C235/34; C07C253/30; C07C255/57; C07C303/22; C07C309/20; C07C309/58; C07D307/91; (IPC1-7): C07C51/353; C07C59/64; C07C67/343; C07C69/612; C07C69/65; C07C69/734; C07C69/738; C07C201/12; C07C205/56; C07C231/12; C07C233/65; C07C253/30; C07C255/57; C07C303/22; C07C309/58; C07D307/91
Domestic Patent References:
| JP5140023A |
Attorney, Agent or Firm:
Akira Asamura (2 outside)