Title:
PRODUCTION OF BETA LACTAMS BY ENZYME
Document Type and Number:
Japanese Patent JPS6363393
Kind Code:
A
Abstract:
N-(3-Carboxyphenylacetyl)-L-cysteinyl-D-valine and N-(3--carboxyphenylacetyl)-L-cysteinyl-D-modified-valine dipeptides are substrates for isopenicillin N synthetase conversion to penams e.g. 2-vinyl-2-methylpenam, 2-allenylpenam and 2-methoxypenam. The substitution of the 3-carboxyphenylacetyl group for the 2- alpha -aminoadipoyl group of the natural tripeptide L-AAA-L-cys-D-val and tripeptides with modified valine affords efficient conversion to the penams.
Inventors:
JIYATSUKU EDOWAADO BOORUDOUIN
Application Number:
JP10299087A
Publication Date:
March 19, 1988
Filing Date:
April 24, 1987
Export Citation:
Assignee:
CHIYANSERAA MASUTAAZU & SUKARA
International Classes:
C07K5/078; C12P37/02; C12P35/00; C12P37/00; (IPC1-7): C12P37/02
Attorney, Agent or Firm:
Aoyama