Title:
PRODUCTION OF PROTEIN MICROSPHERE
Document Type and Number:
Japanese Patent JP2711231
Kind Code:
B2
Abstract:
PURPOSE: To provide a method for preparing a biodegradable protein microsphere controlled or usable for the target systemic or topical medicine delivery and obtain its protein microsphere.
CONSTITUTION: This protein microsphere such as protamine is obtained by passing through (a) a process for bringing a protein solution containing at least one kind of protein into contact with a second liquid which has restricted miscibility with a protein solvent and does not dissolve the protein to form a protein- non-solvent mixture, (b) a process for stirring the protein-non-solvent mixture to form a dispersant of protein solution in the second liquid and (c) a process for removing protein solvent to form the protein microsphere. The protein microsphere has a diameter of 50 nm to 100 μm diameter and the microsphere is not formed by amide bond or thermal denaturation of the protein.
Inventors:
Masiowitz, Edith
Bernstein, Howard
Eric Morell
Schwaler, Kirsten
Bernstein, Howard
Eric Morell
Schwaler, Kirsten
Application Number:
JP8061895A
Publication Date:
February 10, 1998
Filing Date:
April 05, 1995
Export Citation:
Assignee:
Arcames Controlled Therapeutics, Incorporated
International Classes:
A61K9/16; A61K9/50; A61K47/42; B01J13/02; B01J13/08; (IPC1-7): A61K47/42; A61K9/16; B01J13/08
Domestic Patent References:
| JPS61109711A |
Attorney, Agent or Firm:
Shusaku Yamamoto
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