Title:
PROPIONAMIDE DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS5481285
Kind Code:
A
Abstract:
NEW MATERIAL:A propionamide derivative of formula I: (A is O or S; X is N or CH).
EXAMPLE: 2-[10,11-Dihydrodibenzo [b,f] thiepin-2-yl]-propionamide.
USE: Anti-inflammatory drugs.
PROCESS: A compound of formula III or its reactive derivative is reacted with NH3 in the presence of a condensing agent, e.g. dicyclohexylcarbodiimide, etc. in an inert solvent, e.g. methylene chloride, etc. to give the compound of formula I. An acid halide, obtained by reacting the compound of formula III with a halogenating agent, e.g. thionyl chloride, phosphorus pentachloride, or a mixed acid anhydride, obtained by reacting with ethyl chloroformate, etc. may be cited as the reactive derivative.
Inventors:
FUJIMOTO YASUO
YAMABE SHIGERU
YAMABE SHIGERU
Application Number:
JP14880777A
Publication Date:
June 28, 1979
Filing Date:
December 13, 1977
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO
International Classes:
C07D337/14; A61K31/335; A61K31/38; A61P29/00; C07D313/10; C07D313/14; C07D337/10; (IPC1-7): A61K31/335; A61K31/38; C07D313/10; C07D337/10
Domestic Patent References:
| JPS6021156A | 1985-02-02 |