PROTEASE MIXTURE FOR DECREASING GLUTEN IN FOOD

Japanese Patent JP2015063554

A

PROBLEM TO BE SOLVED: To provide formulations used for treating celiac sprue and/or dermatitis herpetiformis.SOLUTION: There are provided pharmaceutical formulations of glutenase enzymes. The enzymes include prolyl endopeptidases (PEP), e.g. the Myxococcus xanthus PEP; and endoprotease, e.g. Hordeum vulgare subsp. vulgare EPB2, and biologically active fragments or derivatives thereof. Certain gluten oligopeptides known to be resistant to cleavage by gastric and pancreatic enzymes are digested by such enzymes, thereby preventing or relieving their toxic effects in celiac sprue or dermatitis herpetiformis patients. The formulations are useful especially for the treatment of celiac sprue or dermatitis herpetiformis patients.

WO/2023/083097	HOT MELT COATING METHOD FOR GRANULAR ENZYME PREPARATION AND APPLICATION THEREOF
JP2002533119	INDUSTRIAL APPLICABILITY: Glycosylphosphatidylinositol-specific phospholipase D protein and its use.

SHAN LU
BETHUNE MICHAEL
KHOSLA CHAITAN
GASS JONATHAN

JP2014256879A

April 09, 2015

December 19, 2014

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UNIV LELAND STANFORD JUNIOR
ALVINE PHARMACEUTICALS INC

A61K38/46; A61K35/74; A61K38/00; A61K38/48; A61P17/04; A61P37/08

WO2003068170A2

2003-08-21

JPN6015049650; Ｐｌａｎｔ　Ｍｏｌ．　Ｂｉｏｌ．，　１９９６，　Ｖｏｌ．３１，　Ｎｏ．２，　ｐｐ．２３９-２５４
JPN6015049645; Ｍｉｋｋｏｎｅｎ，Ａ．，　ｅｔ　ａｌ．: 'ｃｙｓｔｅｉｎｅ　ｐｒｏｔｅｉｎａｓｅ　ＥＰＢ２　ｐｒｅｃｕｒｓｏｒ　［Ｈｏｒｄｅｕｍ　ｖｕｌｇａｒｅ　ｓｕｂｓｐ．　ｖｕｌｇａｒｅ］．'　ＤＡＴＡＢＡＳＥ　ＮＣＢＩ　Ｐｒｏｔｅｉｎ　［ｏｎｌｉｎｅ
JPN6015049647; Ｋｏｅｈｌｅｒ，　Ｓ．Ｍ．，　ｅｔ　ａｌ．: 'ｃｙｓｔｅｉｎｅ　ｐｒｏｔｅｉｎａｓｅ　（ＥＣ　３．４．２２．-）　ＥＰ-Ｂ　４　ｐｒｅｃｕｒｓｏｒ　-　ｂａｒｌｅｙ．'　ＤＡＴＡＢＡＳＥ　ＮＣＢＩ　Ｐｒｏｔｅｉｎ　［ｏｎｌｉｎｅ］　ａｃｃｅｓｓ

Hatsushi Shimizu
Koichi Niimi

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