PROTEIN AGGREGATION-INHIBITING COMPOSITION COMPRISING SACCHARIDE-CONTAINING POLYMER, AND PROTEIN AGGREGATION INHIBITOR COMPRISING THE SAME

Title:

PROTEIN AGGREGATION-INHIBITING COMPOSITION COMPRISING SACCHARIDE-CONTAINING POLYMER, AND PROTEIN AGGREGATION INHIBITOR COMPRISING THE SAME

Document Type and Number:

Japanese Patent JP2008222614

Kind Code:

A

Abstract:

To provide an inhibitor highly efficiently inhibiting aggregation of a protein, particularly an amyloid protein.

The protein aggregation inhibitor comprising a saccharide-containing polymer has been developed based on the findings that a polymer bearing a saccharide in its side chain exhibits high protein aggregation-inhibiting activity, particularly activity for preventing formation of amyloid fibrils, by interacting with an amyloid protein.

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Inventors:

MIURA YOSHIKO
YOU CHOUGA

Application Number:

JP2007061072A

Publication Date:

September 25, 2008

Filing Date:

March 09, 2007

Export Citation:

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Assignee:

JAPAN ADV INST SCIENCE & TECH

International Classes:

A61K31/765; A61P25/00; A61P25/14; A61P25/28; A61P43/00; C08F18/14

Other References:

JPN6012039035; 貫名伸行: '"神経変性疾患の治療展望とトレハロース"' 低温生物工学会誌Ｖｏｌ．５２，Ｎｏ．１, 20060821, Ｐ．２５-２９
JPN6012039037; Ｔａｎａｋａ，Ｍ．　ｅｔ　ａｌ．: 'Ｔｒｅｈａｌｏｓｅ　ａｌｌｅｖｉａｔｅｓ　ｐｏｌｙｇｌｕｔａｍｉｎｅ-ｍｅｄｉａｔｅｄ　ｐａｔｈｏｌｏｇｙ　ｉｎ　ａ　ｍｏｕｓｅ　ｍｏｄｅｌ　ｏｆ　Ｈｕｎｔｉｎｇｔｏｎ　ｄｉｓｅａｓｅ' Ｎａｔｕｒｅ　Ｍｅｄ．Ｖｏｌ．１０，Ｎｏ．２, 200402, Ｐ．１４８-１５４
JPN6012039038; 渡邉亜沙子　外４名: '"beta-アミロイド凝集に及ぼすトレハロースの効果"' 低温生物工学会誌Ｖｏｌ．５１，Ｎｏ．２, 20051230, Ｐ．１３７-１４０
JPN6012039040; 小林一清　外２名: 'ミニレビュー　"糖鎖クラスター材料"' 日本農芸化学会誌Ｖｏｌ．７８，Ｎｏ．９, 20040901, Ｐ．８７０-８７３

Attorney, Agent or Firm:

Takashi Shoji
Yuriko Shinobu
Takuya Osugi

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