Title:
Protein-kinases prevention medicinal spiro loop-like molecule
Document Type and Number:
Japanese Patent JP6062432
Kind Code:
B2
Abstract:
The present invention relates to spirocyclic compounds of formula I, namely spirocyclic (1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amines having protein kinase inhibitory activity, and methods of synthesizing and using such compounds. Preferred compounds are c-Met and/or ALK inhibitors useful for the treatment of abnormal cell growth, such as cancers. R2 is selected from
Inventors:
One, zaoin
Lee, Liang Hai
One, chigan
Lee, Liang Hai
One, chigan
Application Number:
JP2014521885A
Publication Date:
January 18, 2017
Filing Date:
July 26, 2012
Export Citation:
Assignee:
Nanjing Allgen Pharma Co. Ltd.
International Classes:
C07D401/14; A61K31/4439; A61K31/444; A61P35/00; A61P43/00
Domestic Patent References:
| JP2008510788A | ||||
| JP2011511005A | ||||
| JP2009533327A | ||||
| JP2011500778A | ||||
| JP2008510792A | ||||
| JP2006519232A |
Foreign References:
| CN101851237A |
Attorney, Agent or Firm:
Kiyoji Kuzuwa