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Title:
11-β-ヒドロキシステロイドデヒドロゲナーゼ-1の阻害剤としてのピラゾールカルボキサミド
Document Type and Number:
Japanese Patent JP2007501789
Kind Code:
A
Abstract:
Pyrazole carboxamides of structural formula I are selective inhibitors of the 11beta-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.

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Inventors:
Gao, Inn-Doo
Kuh, Shin
Kevin, Nancy Jei
Waddell, Sherman Tay
Application Number:
JP2006522670A
Publication Date:
February 01, 2007
Filing Date:
August 03, 2004
Export Citation:
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Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D231/14; A61K31/415; A61K31/4155; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07D231/16; C07D405/04; C07D409/04; C07D
Domestic Patent References:
JP2006522746A2006-10-05
JP2005507875A2005-03-24
Foreign References:
WO2001057024A12001-08-09
US5258397A1993-11-02
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura



 
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