PYRAZOLE KINASE MODULATOR AND METHOD OF USE

Japanese Patent JP2012153720

A

To provide compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion.

The compounds inhibit, regulate and/or modulate kinases. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention. In one aspect, the present invention provides compounds for modulating c-Kit and flt-3 kinase activity and methods of treating diseases mediated by c-Kit and flt-3 activity utilizing the compounds and pharmaceutical compositions described herein.

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BAIK TAE-GON
BUHR CHRIS A
MA SUNGHOON
NUSS JOHN M
TESFAI ZEROM
WANG LONGCHENG
YEUNG BRYAN K S

JP2012112312A

August 16, 2012

May 16, 2012

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EXELIXIS INC

C07D231/12; A61K31/415; A61K31/4155; A61K31/4184; A61K31/4439; A61K31/496; A61P17/06; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07D401/04; C07D403/04; C07D405/04; C07D405/12; C07D409/04

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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