Title:
PYRIMIDONE DERIVATIVE
Document Type and Number:
Japanese Patent JPS58154579
Kind Code:
A
Abstract:
The invention provides histamine H2-antagonist compounds of formula (I):-
and pharmaceutically acceptable salts thereof, where
W is a 2-furanyl or 2-thienyl group optionally substituted in the 5-position with a group R<1>R<2>N(CH2)a-; a 2-pyridyl group optionally substituted in the 4-or 6-position with a group R<1>R<2>N(CH2)a-; a phenyl group substituted in the 3- or 4-position with a group R<1>R<2>N(CH2)a-; a 4-imidazolyl group optionally substituted in the 5-position with methyl or bromine; a 2-pyridyl group optionally substituted in the 3-position with C1-4 alkyl, C1-4 alkoxy, halogen, amino or hydroxy; a 2-thiazolyl group or a 2-guanidino-4-thiazolyl group;
X is (CH2)b in which b is from 3 to 6, or (CH2)dS(CH2)e in which d and e are the same or different and are from 1 to 3 or, when W is substituted phenyl or 2-pyridyl substituted in the 4- or 6- position with a group R<1>R<2>N(CH2)a-, O(CH2), in which f is from 2 to 5;
Z is hydrogen or C1-4 alkyl;
A is C1-C5 alkylene or (CH2)pA<1>(CH2)q- where A<1> is oxygen or sulphur and p and q are such that their sum is from 1 to 4;
B is an optionally substituted pyridyl, where the optional substituent is one or more C1-4 alkyl. or C1-4 alkoxy or hydroxy groups or halogen atoms or an N-oxo group or a phenyl group optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups or halogen atoms or B is a 6-(2,3-dihydro-1,4-benzodioxinyl) or a 5-(1,3-benzodioxolyl) group or B is a 2-furanyl or 2-thienyl group optionally substituted in the 5-position with a group R<1>R<2>N(CH2)a-; a phenyl group substituted in the 3-of 4-position with a group R<1>R<2>N(CH2)a- or a 3-pyridyl group substituted in the 5- or 6-position or a 4-pyridyl group substituted in the 2-position by a group R<1>R<2>N(CH2)a-;
R<1> and R<2> can be the same or different and are hydrogen or C1-4 alkyl or together form a 1,4-butanediyl, 1,5-pentanediyl, 1,6-hexanediyl or 1,7-heptanediyl group; and a is 1 to 4.
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Inventors:
TOOMASU HENRII BURAUN
Application Number:
JP2545683A
Publication Date:
September 14, 1983
Filing Date:
February 16, 1983
Export Citation:
Assignee:
SMITH KLINE FRENCH LAB
International Classes:
A61K31/505; A61P1/04; A61P43/00; C07D213/38; C07D213/61; C07D213/64; C07D233/54; C07D239/36; C07D277/48; C07D295/096; C07D307/38; C07D307/52; C07D401/06; C07D401/14; C07D403/06; C07D403/14; C07D405/14; C07D417/14; (IPC1-7): C07D401/06; A61K31/505; C07D401/14; C07D405/14; C07D417/14
Attorney, Agent or Firm:
Aoyama Aoi