Title:
ムスカリンＭ１および／またはＭ４受容体アゴニストとしてのキノリノンおよびベンゾオキサジン誘導体
Document Type and Number:
Japanese Patent JP7382406
Kind Code:
B2
Abstract:
This invention related to compounds having activity as muscarinic M1 or M1 and M4 receptor agonists which are useful in the treatment of diseases mediated by the muscarinic M1 and M4 receptors. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula (I) where X1; X2; X3; X4; Y; Z; n, R1 and R2 are defined herein.
Inventors:
Brown, Giles Albert
Congreve, Miles Stuart
Taehan, Benjamin Gerard
Pickworth, mark
Congreve, Miles Stuart
Taehan, Benjamin Gerard
Pickworth, mark
Application Number:
JP2021532237A
Publication Date:
November 16, 2023
Filing Date:
December 09, 2019
Export Citation:
Assignee:
Heptares Therapeutics Limited
International Classes:
C07D413/14; A61K31/4709; A61K31/4995; A61P25/04; A61P25/18; A61P25/28; A61P29/00; A61P43/00; C07D453/06; C07D471/08
Domestic Patent References:
| JP2008524328A |
Foreign References:
| WO2009106534A1 |
Other References:
Journal of Medicinal Chemistry,2014年,57(21),9065-9077
Attorney, Agent or Firm:
Osamu Yamamoto
Toru Miyamae
Junichi Matsuo
Akiko Yamaguchi
Toru Miyamae
Junichi Matsuo
Akiko Yamaguchi