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Title:
RACEMIZATION OF OPTICALLY ACTIVE ALPHA-ISOPROPYL-P-CHLOROPHENYLACETIC ACID OR ITS DIASTEREOISOMER SALT
Document Type and Number:
Japanese Patent JPH02292235
Kind Code:
A
Abstract:

PURPOSE: To racemize optically active α-isopropyl-p-chlorophenylacetic acid or a diastereoisomer salt thereof advantageously at a high speed without requiring high temperature and long time by treating the compound with an organic strong base in the presence of an organic solvent.

CONSTITUTION: Optically active α-isopropyl-p-chlorophenylacetic acid or a diastereoisomer salt thereof is racemized with an organic strong base in the presence of an organic solvent at 100 to 250°C, preferably 100 to 200°C. The organic strong base includes 1,8-diazabicyclo[5,4,0]7-undecene (hereinafter referred to as DBU) and is employed in an amount of 0.1 to 1.0 times mole that of the abovementioned optically active compound. The organic solvent is preferably a hydrophobic organic solvent such as benzene or toluene and is preferably used in an amount of ≤20wt. times that of the DBU when the DBU is employed.


Inventors:
ODA YOSHIAKI
MINAMII MASAYOSHI
Application Number:
JP11567389A
Publication Date:
December 03, 1990
Filing Date:
May 08, 1989
Export Citation:
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Assignee:
SUMITOMO CHEMICAL CO
International Classes:
C07B55/00; C07C51/353; C07C57/58; (IPC1-7): C07B55/00; C07C51/353; C07C57/58
Domestic Patent References:
JPS5528952A1980-02-29
JPS5748539A1982-03-19
JPS6466143A1989-03-13
Attorney, Agent or Firm:
Mitsuhiro Moroishi (1 person outside)