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Title:
RADIOHALOGENATED COMPOUND FOR LABELING PROTEIN AND LABELED PROTEIN THEREBY
Document Type and Number:
Japanese Patent JPH08143490
Kind Code:
A
Abstract:

PURPOSE: To obtain the subject new compound useful for labeling an antibody, and the subject new labeled protein labeled by the compound and useful as a diagnostic agent and therapeutic agent for clinical diagnosis and treatment.

CONSTITUTION: This radiohalogenated compound is represented by the formula *X-Ar-R (*X is a radioactive isotope of I, Br, F and At; Ar is an aromatic or heteroaromatic ring; R is a short chain substituent such as a phenol, an ester, an acid anhydride, a thiol and a hydrazine, not highly activating the before ring to be substituted with the before radioactive isomer, and bearing a functional group suitable for conjugation to a protein under a condition that preserves the biological activity of the protein), e.g. N-succinimidyl 3-(4'-[131 I]iodophenyl)-propionate. The radiohalogenated protein is obtained by reacting the before radiohalogenated compound with the protein preferably in a protonic solvent to prepare the radiohalogenated protein.


Inventors:
WILBUR DANIEL SCOTT (US)
FRITZBERG ALAN RICHARD (US)
JONES DAVID SCHUSTER (US)
Application Number:
JP1995000130844
Publication Date:
June 04, 1996
Filing Date:
May 29, 1995
Export Citation:
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Assignee:
NEORX CORP
International Classes:
C07K14/575; A61K35/16; A61K38/00; A61K38/16; A61K39/395; A61K51/00; A61K51/02; A61K51/08; C07B31/00; C07B59/00; C07C17/00; C07C17/20; C07C25/02; C07C25/18; C07C45/00; C07C47/52; C07C47/55; C07C51/00; C07C57/58; C07C57/60; C07C67/00; C07C67/307; C07C69/65; C07C69/76; C07C209/00; C07C211/52; C07C233/64; C07C233/65; C07C243/22; C07C257/08; C07C313/00; C07C319/12; C07C323/09; C07C325/00; C07C331/28; C07D521/00; C07F3/12; C07F7/22; C07F15/00; C07K1/113; C07K1/13; C07K14/00; C07K16/00; G01N33/534; G01N33/58; G01N33/60; G01N33/68; (IPC1-7): C07C25/02; A61K51/00; C07B59/00; C07C25/18; C07C47/55; C07C233/65; C07C319/12; C07C323/09; C07C331/28; C07K14/00; G01N33/534; G01N33/58; G01N33/60; G01N33/68
Domestic Patent References:
JPS5318568A1978-02-20
Foreign References:
US4115374A1978-09-19
Attorney, Agent or Firm:
吉村 悟