PURPOSE: To obtain the subject new compound useful for labeling an antibody, and the subject new labeled protein labeled by the compound and useful as a diagnostic agent and therapeutic agent for clinical diagnosis and treatment.
CONSTITUTION: This radiohalogenated compound is represented by the formula *X-Ar-R (*X is a radioactive isotope of I, Br, F and At; Ar is an aromatic or heteroaromatic ring; R is a short chain substituent such as a phenol, an ester, an acid anhydride, a thiol and a hydrazine, not highly activating the before ring to be substituted with the before radioactive isomer, and bearing a functional group suitable for conjugation to a protein under a condition that preserves the biological activity of the protein), e.g. N-succinimidyl 3-(4'-[131 I]iodophenyl)-propionate. The radiohalogenated protein is obtained by reacting the before radiohalogenated compound with the protein preferably in a protonic solvent to prepare the radiohalogenated protein.
FRITZBERG ALAN RICHARD (US)
JONES DAVID SCHUSTER (US)
| JPS5318568A | 1978-02-20 |
| US4115374A | 1978-09-19 |