Title:
RECAPITULATING HEMATOPOIETIC NICHE TO RECONSTITUTE IMMUNITY
Document Type and Number:
Japanese Patent JP2022166291
Kind Code:
A
Abstract:
To provide recapitulation of a hematopoietic niche to reconstitute the immunity.SOLUTION: Disclosed are compositions and related methods for recapitulating bone marrow stroma using scaffold materials (e.g., a porous alginate hydrogel scaffold) containing one or more cellular differentiation factors and one or more growth factors. Such methods and compositions promote formation of an ectopic nodule or site that can improve transplanted cell engraftment and selectively drive development of lymphocytes and reconstitution of the adaptive immunity after a hematopoietic stem cell transplant. For example, the invention provides a composition comprising a porous implantable scaffold material, one or more growth factors and one or more differentiation factors, and optionally one or more homing factors.SELECTED DRAWING: None
Inventors:
Nisag Jay Shah
Tin-yu See
Angelo Mao
David Jay. Mooney
David Tea. Skaden
Tin-yu See
Angelo Mao
David Jay. Mooney
David Tea. Skaden
Application Number:
JP2022133258A
Publication Date:
November 01, 2022
Filing Date:
August 24, 2022
Export Citation:
Assignee:
President and Fellows of Harvard College
The General Hospital Corporation
The General Hospital Corporation
International Classes:
A61K38/18; A61K9/00; A61K9/06; A61K38/16; A61K38/17; A61K38/20; A61K45/08; A61K47/36; A61L27/16; A61L27/18; A61L27/20; A61L27/22; A61L27/24; A61L27/52; A61L27/54; A61L27/56; A61P37/02
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki
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