神経障害治療用のリーリン組成物

Japanese Patent JP7253800

B2

Changes in Reelin levels as well as Reelin signaling alter cognitive function. This can be accomplished by administering a therapeutically effective amount of a repeat fragment of Reelin, or a construct formed from fragment repeats of Reelin to a patient or subject. Changes to Reelin levels can be used to treat various neurodegenerative diseases, neuronal insults, or stroke, such as fragile X syndrome, William's syndrome, Rett syndrome, Down's syndrome, Angelman syndrome, autism, ischemia, hypoxia, Alzheimer's disease, and schizophrenia. Reelin can also be used to alter dendritic spine density, diminished long-term potentiation, and diminished synaptic plasticity and associative learning deficits. Constructs formed from repeat region 3 of full length Reelin and repeat region 5 of full length Reelin, or repeat region 3 of full length Reelin and repeat region 6 of full length Reelin have been found particularly useful.

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Weaver, Edwin Jae

JP2019505258A

April 07, 2023

August 03, 2017

Click for automatic bibliography generation  

University of South Florida

A61K35/76; A61K48/00; A61P25/00; A61P25/18; A61P25/24; A61P25/28; A61P43/00

JP2016503405A
JP2015520161A

WO2015013148A2
WO2016100575A1

European Journal of Neuroscience,2015年,41,p.1372-1380
Frontiers in Cellular Neuroscience,2016年03月,10,Article75,p.1-8
Database GenBank: AAC51105.1,1997年02月24日,DeSilvia,U.et al.,DEFINITION:reelin [Homo sapiens], retrieved on 07.Jan.2022

Takahiro Ozaki

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