Title:
ホスホリパーゼCガンマの調節、並びにそれによる疼痛及び侵害受容の制御
Document Type and Number:
Japanese Patent JP2007537167
Kind Code:
A
Abstract:
The present invention provides methods of preventing and treating pain, by modulating, e.g. inhibiting, the activity, function and/or expression of a PLCγ in a subject. The invention further relates to methods of identifying agents capable of modulating the activity and/or expression of a PLCγ, or capable of modulating binding of a ligand or binding partner to a PLCγ, and their use thereof for the prevention and/or treatment of pain. In a further aspect, the invention provides methods for the diagnosis and prognostication of pain by determining whether there is modulation of activity and/or expression of a PLCγ relative to a corresponding control.
Inventors:
Cowl Jeffrey A. M.
Cargentie, Gerald
Cargentie, Gerald
Application Number:
JP2007511816A
Publication Date:
December 20, 2007
Filing Date:
May 13, 2005
Export Citation:
Assignee:
UNIVERSITE LAVAL
International Classes:
A61K45/00; A61K31/132; A61K31/265; A61K31/4015; A61K31/575; A61K31/661; A61K31/685; A61K31/7036; A61K31/7048; A61K31/7088; A61K31/7105; A61K31/713; A61K39/395; A61K48/00; A61P1/00; A61P1/04; A61P3/10; A61P5/00; A61P19/02; A61P25/00; A61P25/02; A61P29/00; A61P29/02; A61P31/18; A61P31/22; A61P35/00; A61P37/04; A61P37/06; A61P43/00; C07H15/232; C07J43/00; C07K16/40; C12N15/113; C12Q1/02; C12Q1/44; G01N33/50; C12N15/09
Domestic Patent References:
| JPH10510540A | 1998-10-13 |
Attorney, Agent or Firm:
Masayuki Masabayashi
Ryoichi Takaoka
Hayashi Ichiyoshi
Kiyoshi Kato
Ryoichi Takaoka
Hayashi Ichiyoshi
Kiyoshi Kato
Previous Patent: レトロウイルスプロテアーゼ阻害剤として有用なリトナビル類似化合物、...
Next Patent: 高分子カップリング剤およびそれらから製造された薬学的に活性のあるポ...
Next Patent: 高分子カップリング剤およびそれらから製造された薬学的に活性のあるポ...