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Title:
RESIN FOR CHEMICAL SYNTHESIS HAVING IMPROVED FUNCTIONAL GROUP AND PRODUCTION OF AMIDE-BASED COMPOUND USING THE SAME
Document Type and Number:
Japanese Patent JPH1067724
Kind Code:
A
Abstract:

To obtain the subject compound to be based for synthesizing an amide- like compound useful for producing a small amount sample for biological screening by reacting a specific acetic acid product with an aminomethyl resin in the presence of a dehydrating agent.

This compound expressed by the formula I {[P] is a supporter; R1, R2 and R3 are each H, a 1-6C alkyl, etc.; R is F, Cl, etc.; (n) is 0-3; (m) is an amount of aldehyde} or formula II (e.g. a resin-bonded compound or an amide-like compound) is obtained by, e.g. in the formula I, reacting indol-3- carboxyaldehyde with a halogen acetate in a suitable solvent and in the presence of a base, then hydrolyzing the resultant product by a slightly caustic compound, thus generating 3-formyl-indol-1-yl-acetic acid. Next, the indole acetate product is reacted with a suspended aminomethyl resin in an inert solvent at a room temperature in the presence of a dehydrating agent (e.g. carbodiimide) for a sufficient time to produce the compound of the formula I.


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Inventors:
ESTEP KIMBERLY GAIL
ROSKAMP ERIC J
Application Number:
JP8832197A
Publication Date:
March 10, 1998
Filing Date:
April 07, 1997
Export Citation:
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Assignee:
PFIZER
International Classes:
C07D209/12; C07B43/06; C07C231/08; C07C233/05; C07C233/25; C07C275/24; C07K1/04; C08F8/30; (IPC1-7): C07C233/05; C07B43/06; C07C231/08; C07C233/25; C07C275/24; C08F8/30
Attorney, Agent or Firm:
Kazuo Shamoto (4 outside)



 
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