To obtain samples from surface array spots having analytes by the automated sampling system and a method of analysis using an electronic spray.
The system includes at least one probe, the probe including an inlet for flowing at least one kind of eluting solvent to respective ones of a plurality of spots and an outlet for delivering the analyte away from the spots. An automatic positioning system is provided for translating the probe relative to the spot to permit sampling of any spot. An electrospray ion source having an input connected by fluidity to the probe receives the analyte and generates ions from the analyte. The ion source provides the generated ions to a structure for analysis to identify the analyte, preferably being a mass spectrometer. The probe can be a surface contact probe, where the probe forms an enclosing seal along the periphery of the array spot surface.
| US5245185A | 1993-09-14 |
Makoto Onda
Atsushi Honda
Miho Ikegami
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