Title:
糖尿病の処置に有用な薬物のスクリーニング方法
Document Type and Number:
Japanese Patent JP2005512546
Kind Code:
A
Abstract:
Methods for screening agents effective against diabetes or preventing the onset of diabetes, in particular Type 2 diabetes, are provided. In one aspect of the invention, the method encompasses assaying for PAI-1 activity in the presence of a candidate agent; and correlating a decrease in PAI-1 activity relative to when the candidate agent is absent with the presence of a potential agent effective against diabetes. Alternatively, E2F activity is detected, an increase in E2F activity reflecting a decrease in PAI-1 activity. Also provided are methods for inhibiting PAI-1 activity, pharmaceutical agents and compositions.
Inventors:
Kazuhiko Hanagi
Yoshimine Nagamine
Yoshimine Nagamine
Application Number:
JP2003552991A
Publication Date:
May 12, 2005
Filing Date:
December 13, 2002
Export Citation:
Assignee:
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
International Classes:
G01N33/50; A61K38/00; A61K38/17; A61K39/395; A61P3/04; A61P3/10; A61P43/00; C12N15/09; C12Q1/56; C12Q1/68; G01N33/15; (IPC1-7): C12Q1/68; A61K38/00; A61K39/395; A61P3/04; A61P3/10; A61P43/00; C12N15/09; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima