SELECTIVE INHIBITION OF AGGRECANASE IN TREATING OSTEOARTHROPATHY

Title:

SELECTIVE INHIBITION OF AGGRECANASE IN TREATING OSTEOARTHROPATHY

Document Type and Number:

Japanese Patent JP2003040800

Kind Code:

A

Abstract:

To provide a pharmaceutical composition containing a small molecule which is an agent selectively suppressing aggrecanase for treating osteoarthropathy.

A pharmaceutical composition for treating a medical state in which a joint cartilage is broken in a mammal. The pharmaceutical composition contains an aggrecanase inhibitor having IC50 of <20 nM, and exhibiting distinctive effects on matrix metalloproteinases(MMPs), a disintegrin and metalloproteinases (ADAMs or reprolysins).

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Inventors:

NOE MARK CARL
MICHAEL ANTHONY RETAVICK
HAWKINS JOEL MICHAEL

Application Number:

JP2002210977A

Publication Date:

February 13, 2003

Filing Date:

August 10, 2000

Export Citation:

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Assignee:

PFIZER PROD INC

International Classes:

A61K31/445; A61K31/495; A61P1/00; A61P1/02; A61K45/00; A61P1/04; A61P3/10; A61P7/00; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P17/02; A61P19/02; A61P19/10; A61P21/00; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/14; A61P25/16; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D211/42; C07D211/96; C07D241/04; C07D241/08; C07D333/34; (IPC1-7): A61K45/00; A61P19/02; A61P29/00; A61P43/00

Attorney, Agent or Firm:

Kazuo Shamoto (4 outside)

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