Title:
(+)-シス-セルトラリンの選択的な製造方法
Document Type and Number:
Japanese Patent JP5456871
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a method for selectively producing (+)-cis-sertraline represented by formula 1 and usable as an intermediate in the production of sertraline hydrochloride.SOLUTION: The method for producing the (+)-cis-sertraline represented by formula 1 includes a step for producing (+)-cis-sertraline (S)-(-)-2-pyrrolidone-5-carboxylate by reacting (±)-cis/trans-sertraline or (±)-cis-sertraline with (S)-(-)-2-pyrrolidone-5-carboxylic acid, and carrying out optical resolution thereof.
Inventors:
Kim, Jehaku
Li, John Kwan
Sun, Yongho
Lee, Songk
Nam, Une
Li, John Kwan
Sun, Yongho
Lee, Songk
Nam, Une
Application Number:
JP2012245642A
Publication Date:
April 02, 2014
Filing Date:
November 07, 2012
Export Citation:
Assignee:
BORYUNG PHARMACEUTICAL CO., LTD.
International Classes:
C07C209/88; C07C211/42; C07B57/00
Domestic Patent References:
| JP5686137A | ||||
| JP2009500425A |
Attorney, Agent or Firm:
Takashima Ichi