Title:
SERUM ALBUMIN BINDING MOLECULES
Document Type and Number:
Japanese Patent JP2018057368
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compounds that increase the serum half-lives of various therapeutics, compounds having increased serum half-lives, and methods for increasing the serum half-lives of therapeutics.SOLUTION: The invention provides a polypeptide comprising a fibronectin type III tenth (10Fn3) domain, where the 10Fn3 domain binds to domain 1 or 2 of human serum albumin with KD of 1 μM or less, and where the serum half-life of the polypeptide in the presence of albumin is at least 5 times greater than the serum half-life of the polypeptide in the absence of serum albumin. The invention also provides a fusion polypeptide comprising serum albumin-binding 10Fn3, and uses thereof.SELECTED DRAWING: None
Inventors:
MICHAEL L GOSSELIN
DAVID FABRIZIO
JOANNA F SWAIN
TRACY S MITCHELL
RAY CAMPHAUSEN
SHARON T CLOAD
FURFINE ERIC
PAUL E MORIN
RANJAN MUKHERJEE
TAYLOR SIMEON I
DAVID FABRIZIO
JOANNA F SWAIN
TRACY S MITCHELL
RAY CAMPHAUSEN
SHARON T CLOAD
FURFINE ERIC
PAUL E MORIN
RANJAN MUKHERJEE
TAYLOR SIMEON I
Application Number:
JP2017185708A
Publication Date:
April 12, 2018
Filing Date:
September 27, 2017
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO
International Classes:
C12N15/09; A61K38/39; A61P1/14; A61P3/04; A61P3/06; A61P3/08; A61P3/10; A61P9/00; A61P43/00; C07K14/47; C07K14/78; C07K19/00; C12N1/21; C12N5/10
Domestic Patent References:
| JP6219357B2 | 2017-10-25 | |||
| JP2010510315A | 2010-04-02 | |||
| JP2013520426A | 2013-06-06 | |||
| JP2013531613A | 2013-08-08 |
Foreign References:
| WO2009102421A2 | 2009-08-20 | |||
| WO2009133208A1 | 2009-11-05 |
Attorney, Agent or Firm:
Samejima Mutsumi
Kenji Tomita
Fumio Inai
Kenji Tomita
Fumio Inai