アンドロゲン受容体遺伝子に特異的なsiRNA - National University Corporation Ehime University

Title:

アンドロゲン受容体遺伝子に特異的なsiRNA

Document Type and Number:

Japanese Patent JP4961549

Kind Code:

B2

Abstract:

To obtain a clinically applicable siRNA (small interference RNA) targeting an AR (androgen receptor) gene.

The double-stranded siRNA is a double-stranded siRNA that targets an AR gene and is a double-stranded siRNA of 21 bases comprising 19 base pairs and 2 base 3' terminal overhangs or a double-stranded siRNA of blunt end comprising 27 base pairs in which the sequence of the 19 base pairs is a specific sequence and the sequence of the 27 base pairs is a specific sequence. Mediating an AR gene-specific RNAi while avoiding an off-target effect and interferon response, the double-stranded siRNA is clinically applicable and is useful in the field of a therapy and a pharmaceutical composition using an AR as a target molecule, for example, in the field of a therapy and a pharmaceutical composition related to a cancer therapy including prostatic cancer.

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Inventors:

Nakaichi Koichi
Hiroyuki Hamakawa

Application Number:

JP2006039768A

Publication Date:

June 27, 2012

Filing Date:

February 16, 2006

Export Citation:

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Assignee:

National University Corporation Ehime University

International Classes:

C12N15/09; A61K47/42; A61K48/00; A61P35/00; C12N15/113

Domestic Patent References:

JP2005529153A
JP2005061717A1
JP2006006262A

Foreign References:

WO2005074995A1
WO2004045543A1

Other References:

J Steroid Biochem Mol Biol., 2005年, 第96巻, 251-258ページ
BENYI LI, Annual Report for the Project W81XWH-04-1-0214, University of Kansas Medical School, 2005年2月
Cancer Cell Int., 2005年, 第5巻, 8
Virology, 2005年, 第336巻, 51-59ページ
Database DDBJ/EMBL/GenBank[online], Accession No.NM_000044, , 08-Jan-2006 uploaded, MARQUES, RB. et al., [retrieved on 17-Jun-2011], Definition:Homo sapiens androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) (AR), transcript variant 1, mRNA.
Cancer Res., 2004年, 第64巻, 3365-3370ページ
N Engl J Med., 1995年, 第332巻, 1393-1398ページ

Attorney, Agent or Firm:

Ikeuchi, Sato & Partners

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