WT1遺伝子の発現を抑制するsiRNAおよびその利用

Title:

WT1遺伝子の発現を抑制するsiRNAおよびその利用

Document Type and Number:

Japanese Patent JP5165890

Kind Code:

B2

Abstract:

The present inventors discovered that siRNAs targeting the 17AA site of the WT1 gene not only suppress the expression of the WT1 gene, but also demonstrate remarkable cell growth-suppressing effects and cell death-inducing effects in cancer cell lines.

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Inventors:

Haruo Sugiyama
Ono Yusuke

Application Number:

JP2006511573A

Publication Date:

March 21, 2013

Filing Date:

March 29, 2005

Export Citation:

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Assignee:

Haruo Sugiyama

International Classes:

A61K31/713; A61K31/7088; A61K31/711; A61K35/76; A61K48/00; A61P35/00; A61P35/02; C12N5/10; C12N15/09; C12N15/113

Other References:

JPN6011025357; ＭＵＲＡＴＡ，Ｙ．　ｅｔ　ａｌ: 'Ｔｈｅ　Ｗｉｌｍｓ　ｔｕｍｏｒ　ｓｕｐｐｒｅｓｓｏｒ　ｇｅｎｅ　ＷＴ１　ｉｎｄｕｃｅｓ　Ｇ１　ａｒｒｅｓｔ　ａｎｄ　ａｐｏｐｔｏｓｉｓ　ｉｎ　ｍｙｅｌｏｂｌａｓｔｉｃ　ｌｅｕｋｅｍｉａ　Ｍ１　ｃｅｌｌ' ＦＥＢＳ　ＬｅｔｔＶｏｌ．４０９，　Ｎｏ．１, 1997, ｐ．４１-５
JPN6011025359; ＩＮＯＵＥ，Ｋ．　ｅｔ　ａｌ: 'Ｗｉｌｍｓ'　ｔｕｍｏｒ　ｇｅｎｅ　（ＷＴ１）　ｃｏｍｐｅｔｅｓ　ｗｉｔｈ　ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ-ｉｎｄｕｃｉｎｇ　ｓｉｇｎａｌ　ｉｎ　ｈｅｍａｔｏｐｏｉｅｔｉｃ　ｐｒｏｇｅｎｉｔｏｒ　ｃｅ' ＢｌｏｏｄＶｏｌ．９１，　Ｎｏ．８, 1998, ｐ．２９６９-７６
JPN6011025361; ＯＪＩ，Ｙ．　ｅｔ　ａｌ: 'Ｅｘｐｒｅｓｓｉｏｎ　ｏｆ　ｔｈｅ　Ｗｉｌｍｓ'　ｔｕｍｏｒ　ｇｅｎｅ　ＷＴ１　ｉｎ　ｓｏｌｉｄ　ｔｕｍｏｒｓ　ａｎｄ　ｉｔｓ　ｉｎｖｏｌｖｅｍｅｎｔ　ｉｎ　ｔｕｍｏｒ　ｃｅｌｌ　ｇｒｏｗｔｈ' Ｊｐｎ　Ｊ　Ｃａｎｃｅｒ　ＲｅｓＶｏｌ．９０，　Ｎｏ．２, 1999, ｐ．１９４-２０４
JPN7011001753; ＤＡＶＩＥＳ，Ｊ．Ａ．　ｅｔ　ａｌ: 'Ｄｅｖｅｌｏｐｍｅｎｔ　ｏｆ　ａｎ　ｓｉＲＮＡ-ｂａｓｅｄ　ｍｅｔｈｏｄ　ｆｏｒ　ｒｅｐｒｅｓｓｉｎｇ　ｓｐｅｃｉｆｉｃ　ｇｅｎｅｓ　ｉｎ　ｒｅｎａｌ　ｏｒｇａｎ　ｃｕｌｔｕｒｅ　ａｎｄ　ｉｔｓ　ｕｓ' Ｈｕｍ　Ｍｏｌ　ＧｅｎｅｔＶｏｌ．１３，　Ｎｏ．２, 2004, ｐ．２３５-４６

Attorney, Agent or Firm:

Hatsushi Shimizu
Koichi Niimi

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