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Title:
SIALIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JPH07228592
Kind Code:
A
Abstract:

PURPOSE: To obtain a new compound useful as a therapeutic agent for geriatric dementia, etc., including Alzheimer's disease, due to its activity of activating ChAT in cholinergic neurocytes.

CONSTITUTION: A compound of formula I [R1 is a steroid compound residue; R2 is H or a 1-4C alkyl; R3 is a 1-15C alkyl, formula II (R6 and R7 are each H, a halogen, a 1-4 alkyl, OH, etc.; (1) is 0-6), etc.; R4 is H or a 2-7C acyl; R5 is R14O (R14 is H or a 2-7C acyl), etc.; X is O or S], e.g. 3α-[N-(3-deoxy-2-O- methyl-α-D-glycero-D-galacto-2-nonulopyranosonyl)amino] cholestane. This compound of formula I is obtained by reacting a compound of formula III (R4' is a 2-7C acyl) with a compound of formula IV, chlorinating the product, then reacting a compound of the formula R3OH with the same.


Inventors:
Chagi, Haruyuki
Ando, Naoko
Morinaka, Yasuhiro
Saito, Kenichi
Yoshigami, Tomoko
Yoshida, Rie
Application Number:
JP1994000318567
Publication Date:
August 29, 1995
Filing Date:
December 21, 1994
Export Citation:
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Assignee:
MITSUBISHI CHEM CORP
International Classes:
A61K31/575; A61K31/704; A61P25/00; A61P25/28; C07J17/00; C07J31/00; C07J41/00; (IPC1-7): C07J41/00; A61K31/575; A61K31/705; C07J17/00; C07J31/00
Attorney, Agent or Firm:
長谷川 曉司