Title:
SINGLE-DOMAIN ANTIBODIES AND VARIANTS THEREOF AGAINST TIGIT
Document Type and Number:
Japanese Patent JP2023160982
Kind Code:
A
Abstract:
To provide single-domain antibodies and variants thereof against TIGIT.SOLUTION: Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes TIGIT. Also provided are methods of making and using these constructs. The present invention relates to anti-TIGIT constructs comprising an sdAb moiety that specifically recognizes TIGIT (hereinafter referred to as "anti-TIGIT sdAb"), such as anti-TIGIT sdAb, anti-TIGIT sdAb-Fc fusion protein comprising an anti-TIGIT sdAb fused to a crystalline fragment (Fc) fragment of human immunoglobulin G (IgG), and multispecific (such as bispecific) antigen binding protein comprising an anti-TIGIT sdAb, e.g., fused to other sdAbs or fused to a full-length four-chain antibody, and methods of making and using them.SELECTED DRAWING: None
Inventors:
WANG JIAN
WU SHU
YANG SHUAI
PAN QI
CHOU CHUAN-CHU
WU SHU
YANG SHUAI
PAN QI
CHOU CHUAN-CHU
Application Number:
JP2023148427A
Publication Date:
November 02, 2023
Filing Date:
September 13, 2023
Export Citation:
Assignee:
NANJING LEGEND BIOTECH CO LTD
International Classes:
C12N15/13; A61K39/395; A61K47/65; A61P31/12; A61P35/00; A61P37/02; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/62; C12N15/63
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto