SOLUTION FOR DIAGNOSING OR TREATING TISSUE PATHOLOGY

Title:

SOLUTION FOR DIAGNOSING OR TREATING TISSUE PATHOLOGY

Document Type and Number:

Japanese Patent JP2010163445

Kind Code:

A

Abstract:

To provide a composition for diagnosing and/or treating cancerous pathologies in the field of urology.

The invention relates to a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation useful for diagnosing and/or treating tissue pathologies and/or cell pathologies by local radiation exposure using radiation emitted by a light source energy followed, in the case diagnosis, by detection of fluorescent protoporphyrin IX (PpIX). The E-ALA concentration (c) in the solution is less than 1% and ranges between 0.01 to 0.5%. The low E-ALA concentration in the solution increases the synthesis of PpIX and homogenizes its distribution in the cell layers while highly reducing the secondary toxicity for the treated cells.

Inventors:

MARTI ALEXANDRE
LANGE NORBERT
ZELLWEGER MATTHIEU
WAGNIERES GEORGE
VAN DEN BERGH HUBERT
JICHLINSKI PATRICE
KUCERA PAVEL

Application Number:

JP2010051284A

Publication Date:

July 29, 2010

Filing Date:

March 09, 2010

Export Citation:

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Assignee:

MARTI ALEXANDRE
LANGE NORBERT
JICHLINSKI PATRICE
KUCERA PAVEL
ECOLE POLYTECH

International Classes:

A61K41/00; A61K9/08; A61K49/00; A61K31/197; A61K31/22; A61K31/221; A61K47/02; A61K47/10; A61K47/18; A61P35/00

Foreign References:

WO1996028412A1

1996-09-19

Attorney, Agent or Firm:

Keiichi Ota

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