Title:
癌を治療するためのインテグリンリガンドを用いる特異的療法および薬剤
Document Type and Number:
Japanese Patent JP2010533665
Kind Code:
A
Abstract:
The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agents or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy. The therapy results in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone, concurrently or not in the dosage regime of the present invention.
Inventors:
Kruger, Stefan
Godman, Simon
Godman, Simon
Application Number:
JP2010516420A
Publication Date:
October 28, 2010
Filing Date:
July 17, 2008
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
A61K45/06; A61K31/282; A61K31/337; A61K31/475; A61K31/513; A61K31/555; A61K31/675; A61K31/704; A61K38/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2010516645A | 2010-05-20 | |||
| JP2004520344A | 2004-07-08 |
Other References:
JPN6013011787; ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ Ｖｏｌ．６２， Ｎｏ．１５, 20020801, ｐ．４２６３-４２７２
JPN6013011789; ＣＬＩＮＩＣＡＬ ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ Ｖｏｌ．１１， Ｎｏ．１７, 20050901, ｐ．６２７０-６２７９
JPN6013011791; ＴＨＥ ＮＥＷ ＥＮＧＬＡＮＤ ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＥ Ｖｏｌ．３５２， Ｎｏ．１０, 20050310, ｐ．９８７-９９６
JPN6013011792; ＩＮＴＥＲＮＡＴＩＯＮＡＬ ＪＯＵＲＮＡＬ ＯＦ ＣＡＮＣＥＲ Ｖｏｌ．１０４， Ｎｏ．４, 2003, ｐ．４９６-５０３
JPN6013011794; ＰＮＡＳ Ｖｏｌ．９６, 199902, ｐ．１５９１-１５９６
JPN6013011789; ＣＬＩＮＩＣＡＬ ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ Ｖｏｌ．１１， Ｎｏ．１７, 20050901, ｐ．６２７０-６２７９
JPN6013011791; ＴＨＥ ＮＥＷ ＥＮＧＬＡＮＤ ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＥ Ｖｏｌ．３５２， Ｎｏ．１０, 20050310, ｐ．９８７-９９６
JPN6013011792; ＩＮＴＥＲＮＡＴＩＯＮＡＬ ＪＯＵＲＮＡＬ ＯＦ ＣＡＮＣＥＲ Ｖｏｌ．１０４， Ｎｏ．４, 2003, ｐ．４９６-５０３
JPN6013011794; ＰＮＡＳ Ｖｏｌ．９６, 199902, ｐ．１５９１-１５９６
Attorney, Agent or Firm:
Akio Miyazaki
Ishibashi Masayuki
Masaaki Ogata
Ishibashi Masayuki
Masaaki Ogata