Title:
PRONANOSPHERE AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JP3148769
Kind Code:
B2
Abstract:
PURPOSE: To provide pronanospheres capable of producing nanospheres when redispersed in a solvent like water.
CONSTITUTION: Nanospheres containing a medicinal substance and phospholipid are, if needed, further incorporated with cholesterol, its derivative, or a substance capable of altering surface charge; the resulting nanospheres are applied on a sugaralcohol like sorbitol as nucleus by fluidized bed granulation process, thus obtaining the objective pronanospheres. Limitation of the weight ratio of the phospholipid to the medicinal substance can control the particle size of the nanospheres after their redispersion in water; furthermore, addition of the cholesterol can suppress particle size increase when the pronanospheres containing the medicinal substance at high concentration are redispersed in a salt-contg. aqueous solution.
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Inventors:
Yoshiaki Kawashima
Hirofumi Takeuchi
Chisho Hino
Toshiyuki Niwa
Tomohiro Yoshinari
Keizo Uesugi
Hiroshi Ozawa
Hirofumi Takeuchi
Chisho Hino
Toshiyuki Niwa
Tomohiro Yoshinari
Keizo Uesugi
Hiroshi Ozawa
Application Number:
JP2336792A
Publication Date:
March 26, 2001
Filing Date:
January 14, 1992
Export Citation:
Assignee:
Eisai Co., Ltd.
International Classes:
A61K9/16; A61K9/127; A61K9/50; A61K9/51; A61K47/24; A61K47/26; A61K47/28; (IPC1-7): A61K9/51; A61K47/24