Title:
ヌクレオシドアナログを調製するための立体選択的な方法
Document Type and Number:
Japanese Patent JP4542776
Kind Code:
B2
Abstract:
A process for producing predominantly cis nucleosides or nucleoside analogues and derivates of formula (A): wherein R1 is a pyrimidine base or a pharmaceutically acceptable derivative thereof and Q is oxygen, carbon or sulphur, comprising a coupling step of the pyrimidine base with a molecule of formula (B) described herein in a suitable coupling solvent, in the presence of catalytic amounts of an element or combination of elements of groups 1B or 11B of the periodic table, a tertiary amine and a Lewis acid to obtained an intermediate of formula (D) which is deprotected in the subsequent step to generate the product of formula (A).
Inventors:
Kin Yu
Application Number:
JP2003506269A
Publication Date:
September 15, 2010
Filing Date:
June 14, 2002
Export Citation:
Assignee:
Shire Canada Incorporated
International Classes:
C07D327/04; C07B61/00; C07D409/04; C07D411/04
Domestic Patent References:
| JP9512526A |
Other References:
CAPUTO,EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,ドイツ,WILEY - VCH VERLAG,1999年,V1455-1458
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
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