Title:
置換アリール誘導体及び置換ヘテロアリール誘導体、それらの調製及び薬物としてのそれらの使用
Document Type and Number:
Japanese Patent JP3827530
Kind Code:
B2
Abstract:
Compounds that prolong thrombin time. Exemplary are:(a) rac-4-{3-[5-ethoxycarbonylmethyl-2-methyl-4-(2-methyl-pyrrolidinocarbonyl)-phenyl]-propargylamino}benzamidine,(b) rac-4-{3-[2,5-dimethyl-4-(2-methyl-pyrrolidinocarbonyl)-phenyl]-propargylamino}benzamidine, and(c) 4-[3-(2,5-dimethyl-4-isopropylcarbonyl-phenyl)propargyl-amino]benzamidine.
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Inventors:
Prepke Henning
Kaufman Iliz
Howell norbert
Leeds Uwe
Naru Herbert
Stassen Yan Marie
Wienen Wolfgang
Kaufman Iliz
Howell norbert
Leeds Uwe
Naru Herbert
Stassen Yan Marie
Wienen Wolfgang
Application Number:
JP2000588121A
Publication Date:
September 27, 2006
Filing Date:
December 13, 1999
Export Citation:
Assignee:
Boehringer Ingelheim Pharma Gesellshaft Mitt Beschlenktel Haftung Und Company Comandito Gesellshaft
International Classes:
A61K31/15; C07C257/18; A61K31/155; C07D295/08; A61K31/167; A61K31/192; A61K31/216; A61K31/223; A61K31/343; A61K31/381; A61K31/397; A61K31/40; A61K31/403; A61K31/404; A61K31/407; A61K31/415; A61K31/4174; A61K31/4184; A61K31/42; A61K31/426; A61K31/44; A61K31/443; A61K31/4465; A61K31/454; A61K31/495; A61K31/496; A61K31/535; A61K31/5355; A61K31/5375; A61K31/5377; A61P7/02; A61P43/00; C07D205/08; C07D207/06; C07D207/08; C07D207/09; C07D207/20; C07D207/335; C07D209/08; C07D211/32; C07D213/50; C07D231/12; C07D233/54; C07D233/60; C07D233/61; C07D233/64; C07D235/08; C07D235/14; C07D261/08; C07D277/24; C07D307/88; C07D333/22; C07D405/04; C07D487/04; C07D235/10
Domestic Patent References:
JP4217958A | ||||
JP4225960A | ||||
JP56103154A | ||||
JP8157435A | ||||
JP3155536B2 | ||||
JP11147866A | ||||
JP2002508370A |
Other References:
Bioorganic & Medicinal Chemistry Letters,1998年,8,p.1877-1882
Bulletin of the Chemical Society of Japan,1995年,68(5),p.1497-1507
Bulletin of the Chemical Society of Japan,1995年,68(5),p.1497-1507
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda