SUBSTITUTED DERIVATIVE OF AMINOALKANDIOL AS GASTRIC SECRETION INHIBITOR

Japanese Patent JPS58116441

A

There are disclosed substituted derivatives of amino alkane diols having the formula:whereinR¹, R², R³ and R⁴ are, e.g., hydrogen or loweralkyl;n and m are 1 or 2;kis 0 to 4;is a 6-membered heterocycle containing one to three nitrogen atoms or a 5-membered heterocycle containing two to three heteroatoms selected from oxygen, sulfur, or nitrogen with the proviso that when either an oxygen or a sulfur atom is present, the remaining heteroatom(s) must be nitrogen or a substituted phenylene; E is a group having the followinp formulae:whereinR⁷ is, e.g., hydrogen or loweralkyl;R⁸ is, e.g., CH₂-aryl;Z and Z' are, e.g., CN;p is 1 or 2; and,the physiologically acceptable, non-toxic salts thereof. These compounds are useful for the suppression of gastric acid secretions in mammals.

JIYON JIEE BOORUDOUIN
UIRIAMU SHII RUMA JIYUNIYA

JP22311382A

July 11, 1983

December 21, 1982

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MERCK & CO INC

A61K31/42; A61K31/421; A61K31/425; A61K31/426; A61K31/433; A61P1/04; A61P43/00; C07C45/71; C07C67/00; C07C213/00; C07C217/56; C07C217/84; C07C229/30; C07C235/46; C07C237/16; C07C237/20; C07C239/00; C07C253/00; C07C255/30; C07C255/59; C07C257/14; C07C279/10; C07C279/28; C07C301/00; C07C307/02; C07C311/00; C07D209/48; C07D213/64; C07D233/70; A61K31/155; C07D263/04; C07D263/16; C07D263/58; C07D275/02; C07D275/03; C07D277/20; C07D277/28; C07D277/34; C07D277/56; C07D285/10; C07D403/14; C07D417/12; C07D417/14; (IPC1-7): C07C93/14; A61K31/155; A61K31/41; A61K31/42; A61K31/425; A61K31/505; C07C101/28; C07C103/187; C07C103/58; C07C121/45; C07C121/80; C07C123/00; C07C143/76; C07C143/86; C07D209/48; C07D263/16; C07D275/02; C07D277/28; C07D277/56; C07D285/10; C07D417/12; C07D417/14

Masao Okabe

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