Title:
チロシンキナーゼ阻害剤としての置換オキシインドール誘導体
Document Type and Number:
Japanese Patent JP2004517049
Kind Code:
A
Abstract:
The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
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Inventors:
Koiper, lee, frederick
Lucky, careen, elizabeth
Wood, third, edgar, raymond
Dickerson, scott, howard
Hunter, Robert, N.
Luzio, Michael, Jay.
Lucky, careen, elizabeth
Wood, third, edgar, raymond
Dickerson, scott, howard
Hunter, Robert, N.
Luzio, Michael, Jay.
Application Number:
JP2002525102A
Publication Date:
June 10, 2004
Filing Date:
August 23, 2001
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
A61K31/404; A61K31/433; A61K31/4439; A61P25/04; A61P29/00; A61P29/02; A61P35/00; A61P43/00; C07D209/34; C07D209/40; C07D401/12; C07D417/12; (IPC1-7): C07D209/34; A61K31/404; A61K31/433; A61K31/4439; A61P25/04; A61P29/02; A61P35/00; A61P43/00; C07D209/40; C07D401/12; C07D417/12
Foreign References:
| WO1999015500A1 | 1999-04-01 |
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Ai Fujii
Satoshi Fujita
Ai Fujii